An HNF4a-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis

Maria Hatziapostolou,1,2 Christos Polytarchou,1,2 Eleni Aggelidou,4 Alexandra Drakaki,5 George A. Poultsides,6 Savina A. Jaeger,7 Hisanobu Ogata,8 Michael Karin,8 Kevin Struhl,3 Margarita Hadzopoulou-Cladaras,4,9 and Dimitrios Iliopoulos1,2,9,* 1Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute 2Department of Microbiology and Immunobiology 3Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School, Boston, MA 02115, USA 4Department of Genetics, Developmental andMolecular Biology, Laboratory of Developmental Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece 5Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA 6Department of Surgery, Stanford University Medical Center, Stanford, CA 94305, USA 7Department of Developmental Molecular Pathways, Novartis Institute for Biomedical Research, Cambridge, MA 02139, USA 8Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA 9These authors contributed equally to this work *Correspondence: [email protected] DOI 10.1016/j.cell.2011.10.043